Extended Data Fig. 7: Cryo-EM structures of the full-length BA.2S protein.

(a) Three structures of the BA.2S trimer, representing the closed prefusion conformation, one-RBD-intermediate conformation and one-RBD-up conformations, were modeled based on corresponding cryo-EM density maps at 2.7 Å, 3.5 Å and 2.9 Å resolution, respectively. Three protomers (a, b, c) are colored in red, blue and green, respectively. RBD locations are indicated. Particle percentage for each class in the data processing is also indicated, but it may not accurately reflect the conformation distribution of the S trimer in solution. (b) Superposition of the three conformations of the BA.2 S trimer aligned by the invariant S2 with only one protomer for each shown for clarity. Three RBDs representing the closed prefusion, one-RBD-intermediate and one-RBD-up conformations are colored in cyan, yellow and orange, respectively.