Fig. 7: A co-translational hierarchical model for TFIID assembly.
From: Hierarchical TAF1-dependent co-translational assembly of the basal transcription factor TFIID
Scheme of the proposed cytoplasmic assembly model for TFIID that reconciles the experimental observations of the present work with previous structural and biochemical data. The assembly pathway can be subdivided into three tiers (colored and numbered horizontal stripes). Tier 3 represents the co-translational assembly of several TFIID building blocks on nascent TAF1 protein through three distinct interaction hotspots (labeled A, B and C), resulting in TFIID. Blue arrows with bases indicate directional co-TA events, and double-headed blue arrows specify reciprocal co-TA, as assessed by RIPs. For further details, see the Discussion section.
