Extended Data Fig. 3: Analysis of Oat1-Sybody complex.
From: Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1
a, Sliced through volume representation of Oat1 showing the electrostatic surface with key structural features highlighted. Electrostatic surface of Oat1. b, Surface display of Oat1 with cartoon display of the sybody binder. The buried solvent accessible surface area (>= 15 Å2) is highlighted in orange. c, Electrostatic surface representation of Oat1 with the buried surface area highlighted. d, The main polar interaction between the sybody and the extracellular domain of Oat1 occurs via the CDR2 loop, with Arg59 hydrogen bonding to the backbone carbonyl group of Lys71 in Oat1. e, The sybody used for structural determination has a KD of 75 nM. n = 4 independent experiments, calculated mean ± s.d. is shown.
