Extended Data Fig. 9: Comparisons of antibiotic-ribosome structures.
From: Structural conservation of antibiotic interaction with ribosomes
a-b, Interaction of spectinomycin (Spc) determined (a) here on E. coli (SpcE.coli) at 1.8 Å (from Fig. 2) and (b) on the E. faecalis 70S ribosome (SpcE.fae.) at 2.4 Å8. c, Superimposition of (a) and (b). d-e, Interaction of spectinomycin (Spc) determined (d) here on E. coli (SpcE.coli) at 1.8 Å (from Fig. 2) and (e) within an E. coli translocation intermate (SpcTrans) at 2.54 Å55. f, Superimposition of (d) and (e). g-h, Interaction of apramycin (Apr) determined (g) here on E. coli (AprE.coli) (from Fig. 2) and (h) within an E. coli translocation intermediate (AprTrans) at 2.35 Å7. i, Superimposition of (g) and (h). j-k, Interaction of (j) gentamicin (Gen) determined here on E. coli (Gen) (from Fig. 2) and (k) paromomycin (Par) on an E. coli bearing mRNA, A- and P-site tRNAs at 1.98 Å12. l, Superimposition of (i) and (j).
