Extended Data Fig. 3: Binding of Lis1 to dynein is sterically incompatible with Phi.
From: Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge
a, Phi dynein (PDB 5NUG) was aligned to dynein1 in Chi, which is shown in gray in this panel. Phi’s dynein2, shown in color, clashes with the Lis1 bound at sitering in Chi’s dynein1. b, Close up of our model of Chi equivalent to the view in (a), showing Lis1 bound at sitering on dynein1. Part of dynein2, with which the Lis1 at sitering interacts in Chi, is also shown.
