Extended Data Fig. 4: The conformation of the linker is different in Chi and Phi.
From: Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge
a, The linker docks onto AAA2 and AAA3 in Phi. b, In contrast, the linker is disengaged from the AAA ring in Chi. c, Overlay of Phi (a) and Chi (b) highlights the different positions of the linker. d, e, The N-termini of the linker adopt different paths in Phi (d) and Chi (e). f, Overlay of Phi (d) and Chi (e) shows how the linkers are pulled apart in Chi.
