Fig. 5: Free energy diagram of the enyzmatic reaction of K-Ras.

Free-energy scheme of K-Ras along its GTPase reaction coordinate for the WT (dark blue) in comparison with the oncogenic G12D (purple) and G12C (orange) mutants.

Free-energy scheme of K-Ras along its GTPase reaction coordinate for the WT (dark blue) in comparison with the oncogenic G12D (purple) and G12C (orange) mutants.