Extended Data Fig. 4: YTHDF proteins CLIP to stress granule-enriched transcripts.
From: m6A governs length-dependent enrichment of mRNAs in stress granules
a, G3BP1 and TIAR show weak correlation between mRNA binding and the level of mRNA enrichment in stress granules. The x-axis indicates the density of eCLIP reads for either G3BP1 or TIAR for each mRNA. The y-axis shows the log2-fold change for mRNA abundance in stress granule mRNAs relative to total mRNAs generated in a previous stress granule transcriptome in U2OS cells5. Both G3BP1 and TIAR show that mRNAs exhibit a relatively small correlation between CLIP read density and stress granule enrichment. n = 7878 transcripts. b, YTHDF proteins show stronger correlations between mRNA binding and the level of mRNA enrichment in stress granules. YTHDF binding and the correlation with stress granule mRNA enrichment was calculated as in c. All the YTHDF proteins show a stronger correlation between stress granule enrichment and CLIP read density compared to G3BP1 and TIAR, with the strongest correlation for YTHDF2. n = 7878 transcripts.
