Extended Data Fig. 6: Sequence alignment of mouse, human, zebrafish and Ciona Myomaker.
From: Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion
a, Sequence alignment. The transmembrane helices (TM), intracellular loops (ICL), extracellular loops (ECL) and the residue numbers of Myomaker are indicated above the protein sequence. The conserved residues and disulfide bond are highlighted in green and indicated beneath the protein sequence, respectively. The specific residues necessary for dimerization and lipid binding and Carey-Fineman-Ziter syndrome (CFZS) causing mutations are indicated by purple, blue and red stars, respectively. m, mouse; h, human; z, zebrafish; c, Ciona. b, The distribution of CFZS-causing mutations.
