Fig. 1: Biochemical reconstitution and cryo-EM structure of the full human NAIP/NLRC4 inflammasome. | Nature Structural & Molecular Biology

Fig. 1: Biochemical reconstitution and cryo-EM structure of the full human NAIP/NLRC4 inflammasome.

From: Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing

Fig. 1: Biochemical reconstitution and cryo-EM structure of the full human NAIP/NLRC4 inflammasome.The alternative text for this image may have been generated using AI.

a, Domain organization of huNLRC4, huNAIP and Needle. b, Purification of huNLRC4 inflammasome with or without R288A mutation and SDS–PAGE of SEC fractions from the peaks (highlighted with bars). These experiments were independently repeated three times. c, Cryo-EM maps of huNLRC4 inflammasome. d, Zoom-in views of CARD domains. Maps are colored by domain organization.

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