Extended Data Fig. 5: Sequence alignment of NLRC4.
From: Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing
a. Conserved residues are highlighted and filled in gray. Residues involved in binding are highlighted using orange and cyan circles for the NACHT-NACHT and LRR-LRR interactions with the NAIP, blue and gray circles with black outlines for the interactions with the front NLRC4, blue and gray circles without black outlines for the interactions with the back NLRC4, respectively. b. Sequence alignments of NLRC4 and NAIP at the ‘LockKey’ regions. Conserved residues are highlighted and filled in gray. Critical residues were highlighted using black and white circles with black outlines, respectively.
