Extended Data Fig. 5: Enriched YC initiation marks radiotherapy responsive CRC tumours. | Nature Structural & Molecular Biology

Extended Data Fig. 5: Enriched YC initiation marks radiotherapy responsive CRC tumours.

From: Intra-promoter switch of transcription initiation sites in proliferation signaling-dependent RNA metabolism

Extended Data Fig. 5

a, Dual initiators were segregated on the basis of whether they contained >1TPM of either TOP or TOP-deg YC forms (With TOP, n = 4819), or not (Without TOP – representing the group of 1466 DIPs with only the YC-other form identified in Fig. 5b). a shows the frequency distribution equivalent to Fig. 3g, but with the ‘With TOP’ and ‘Without TOP’ DI groups shown separately. b, frequency distribution equivalent to Fig. 4b, but with the ‘With TOP’ and ‘Without TOP’ DI groups shown separately. c, frequency distribution plots (analogous to a&b) of the relative ratio of YC:YR transcripts where the YC transcripts are with or without internal TOP sequences (within the first 50 bp) in dual initiators in responsive (gold), moderately-responsive (green) and non-responsive (blue) organoid cohorts. d, frequency distribution plots (analogous to c&d) of the relative activity of YR transcripts with vs. without internal TOP sequences (within the first 50 bp) in consensus clusters in responsive (gold), moderately-responsive (green) and non-responsive (blue) organoid cohorts.

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