Extended Data Fig. 9: Inhibition of PI3K / AKT / mTOR and DNA damage pathway signalling enhances YC transcript abundance and restores radiotherapy induced transcriptional dynamics.
a and b, Plot of survival of organoids from each resistant line, exposed to a combination of drug treatment (a – Omipalisib, b – VE821) and irradiation (Data are presented as mean values +/- SEM). c, Bar graphs of RTqPCR analysis of relative YC/YR expression from candidate dual initiators in CRC organoids treated with Omipalisib and VE821, irradiation or a combination of drug and irradiation (n = 3 independent experiments, * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001, Ordinary one-way ANOVA with Tukey’s multiple comparison’s test, Data are presented as mean values +/- SEM, full list of p-values available presented in the Source data file).
