Extended Data Fig. 5: ΔG of minimum free energy structures and base pairing probabilities of the top 10,000 resistant and sensitive sequences.
Comparison of minimum free energy (MFE) structures’ of ΔG’s from the top 10,000 resistant and sensitive (a) L3 and (b) SVL sequences. For all boxplots, hinges were drawn from the 25th to 75th percentiles, with the middle line denoting the median, and whiskers with maximum 1.5 interquartile range. The ΔG’s are significant with a p-value of < 2.2 × 10−308 for L3 and 1.58 × 10−28 for SVL (two-sided t-test with unequal variance). (c) Heatmap of the difference between top 10,000 resistant and sensitive L3 sequences’ average base pairing probabilities. (d) Same as in panel c but for SVL.
