Extended Data Fig. 10: Conservation and gene ontology analyses for JTE-607-sensitive and –resistant PASs. | Nature Structural & Molecular Biology

Extended Data Fig. 10: Conservation and gene ontology analyses for JTE-607-sensitive and –resistant PASs.

From: The anticancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery

Extended Data Fig. 10

(a) The phyloP sequence conservation score for both resistant and sensitive PASs across different species was calculated and plotted against nucleotide position of the CS. Position 0 is the YA (Y is U or C) cleavage position. (b) Gene ontology analyses of genes that contain the top 1000 sensitive or resistant PAS in HepG2 cells. This analysis was done with gProfiler and the top 6 categories that contain between 5 and 500 genes are listed.

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