Extended Data Fig. 6: AlphaFold Multimer prediction of CCDC22-CCDC93 binding to DENND10.
From: Structural organization of the retriever–CCC endosomal recycling complex
(a) AlphaFold Multimer prediction of DENND10 binding to full-length (FL) CCDC22-CCDC93. (b) Representative AFM models colored using pLDDT scores. (c) PAE score matrix of the AFM model shown in (B). Boundaries of protein sequences and important structure regions are indicated. (d) Superimposition of the AFM model of DENND10 with the crystal structure of DENND1a (PDB: 6EKK). Rab35 binding surface of DENND1a and CCDC22-CCDC93 binding surface of DENN10 are colored to show the partial overlap of the two surfaces.
