Fig. 7: SPT2 regulates chromatin structure and organism fitness.
From: The histone chaperone SPT2 regulates chromatin structure and function in Metazoa
SPT2 localizes to highly active genes where it promotes the maintenance of chromatin structure via its histone H3–H4 binding capacity. Here, it may act via stabilizing new histone H3.3 before their incorporation, as well as via directly promoting their incorporation into chromatin. In worms, the interaction of CeSPT-2 with H3–H4 is required for the transgenerational inheritance of gene silencing and to promote the integrity of the germline under heat stress conditions. Loss of CeSPT-2 in worms activates a stress response, potentially due to aberrant transcription, and makes worms reliant on the HIRA-1 histone chaperone.
