Extended Data Fig. 6: Comparative analysis of conformational variation in the Commander complex structure compared to existing literature, related to Fig. 5.
From: Structure and interactions of the endogenous human Commander complex
a, Overview of the Commander complex structure with location of following panels indicated. Comparison of b the COMMD-ring, c DENND10, I-coil, and R-coil region, d Retriever subcomplex from the structure presented in this study and the overall model presented by Healy et al. e, Comparison of VPS29 with VPS35L (13-37) presented in this study (left) and crystal structure of VPS29 with VPS35L (16-38) peptide (right). Major structural differences are highlighted with yellow, and sources of structural data are indicated for each structure. The three disease mutations analyzed in AP-MS and BioID (Fig. 7) are indicated in d.
