Fig. 7: RSS and XLID related mutations and putative interaction interfaces of the Commander complex. | Nature Structural & Molecular Biology

Fig. 7: RSS and XLID related mutations and putative interaction interfaces of the Commander complex.

From: Structure and interactions of the endogenous human Commander complex

Fig. 7

a, Three mutations associated with RSS or XLID highlighted within the context of the Commander complex structure. b, Effect of A830T mutation on VPS35L in BioID–MS. All PPIs passing HCI criteria to either wild-type VPS35L or VPS35L(A830T) are plotted for both constructs, with HCIs indicated using a black outline and non-HCIs with a light blue outline. Node color corresponds to the bait normalized abundance of the average spectral count for each prey, and node radius to its relative abundance across all baits determined by ProHits-Viz. c, Composite model of the Commander complex, indicating putative interaction interfaces with TPGC. d, Rotated view of the model in c, with putative interaction interface of the WASH complex indicated.

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