Extended Data Fig. 7: Cryo-EM processing flowchart for CUL9-RBX1ΔCPH, CUL9-RBX1ΔARIH-RBR, CUL9-RBX1ΔARM9 and CUL9-RBX1ΔDOC.

a, Representative micrograph and cryo-EM processing scheme for CUL9-RBX1ΔCPH, in which CPH domain was replaced by a linker of sequence GSGSGSGS. b, Representative micrograph and cryo-EM processing scheme for CUL9-RBX1ΔARM9, in which ARM9 domain was replaced by a linker of sequence GSGSGSGS. c, Representative micrograph and cryo-EM processing scheme for CUL9-RBX1ΔARIH-RBR, a variant lacking ARIH-RBR element by truncation at residue 1978. d, Representative micrograph and cryo-EM processing scheme for CUL9-RBX1ΔDOC, in which DOC domain was replaced by a linker of sequence GSGSGSGS.