Extended Data Fig. 9: Sequence alignment of the C1b region.
From: Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia
Residue similarities are colored according to the BLOSUM62 score. Secondary structures of the primary sequence for the AC5 structure here are displayed on top, and the AlphaFold2 predicted model for the C1b region in AC5 is shown at the bottom as a reference for the named helices. The predicted ‘PFAHL’ Gβγ binding site in AC2 is highlighted in an orange box. Residues modelled in contact with Gβγ in the AC5–Gβγ complex (PDB entry 8SL3) are drawn in red color.
