Extended Data Fig. 9: Druggable ligand-binding sites predicted for the Rev1 CTD/Polζ interface. | Nature Structural & Molecular Biology

Extended Data Fig. 9: Druggable ligand-binding sites predicted for the Rev1 CTD/Polζ interface.

From: Cryo-EM structure of the Rev1–Polζ holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis

Extended Data Fig. 9: Druggable ligand-binding sites predicted for the Rev1 CTD/Polζ interface.

Rev1 CTD, Rev7B and a portion of the Rev3-RIR are shown in yellow, green and brown, respectively. Potential ligand binding Site 1 and Site 2, as predicted by FTsite, are shown in salmon and grey colored mesh, respectively. The cluster of probes at each site are shown in sticks. Site 1 represents the Rev1 CTD/Rev7B interface whereas Site 2 highlights the ligand-binding site at Rev1 CTD/Rev7B/Rev3RIR interface.

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