Extended Data Fig. 6: Supplement for Fig. 5.

(a) Correlation of log₂ (old / young) concentration ratios derived from young and old budding yeast mothers and their daughter cells. Each concentration ratio is the average from three replicate experiments. Blue dots are x-binned data and error bars represent the 99% confidence interval. (b) Relative concentrations of core histone proteins in young, middle-aged, and old yeast mothers. Each dot corresponds to 1 of 3 biological replicate experiments. Measurements of the daughters of young, middle-aged, and old mothers is depicted in Fig. 5. (c) Correlation of age-associated and size-dependent proteome changes. Log₂ concentration ratio (old / young) is calculated from mother cells. Protein slope value is from the G1 arrest time experiment in Fig. 2. Measurements of the daughters of young, middle-aged, and old mothers is depicted in Fig. 5. Concentration ratios are the average from three replicate experiments. Blue dots are x-binned data and error bars represent the 99% confidence interval. r value denotes Pearson correlation coefficient. (d) Correlation grid containing size- and age-associated proteomics data. Protein slope values (Fig. 2), log₂ (old / young) concentration ratios for daughters (Fig. 5) and mothers (b), were cross correlated with similar measurements from the literature. Numbers and colors denote Pearson correlation value for indicated datasets.