Extended Data Fig. 8: LBD rearrangements at pH 5.5 versus pH 8.0. | Nature Structural & Molecular Biology

Extended Data Fig. 8: LBD rearrangements at pH 5.5 versus pH 8.0.

From: Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization

Extended Data Fig. 8

a, Displacements of the LBD tier induced by pH are summarized as mode vectors using Pymol (black line with red arrowhead). The consensus map at pH 8.0 and pH 5.5, which represent global average of all sub-classes, were used for comparison. The two structures were aligned at the M3 helices in the TMD which adopt virtually identical structures. LBD subunits are labeled as A-D. Pore central axis is indicated with a black diamond (top) and a broken arrow (bottom). b, The D1 lobes of the LBD tier, the subdomain closer to the NTD tier, at pH 8.0 and pH 5.5 are superimposed as described above. Red arrow: shortening of distance between the D1 lobes at pH 5.5. Inset: rearrangements of their G helices at Ala665.

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