Extended Data Fig. 4: Functional roles of Pol ε amino acid side chains involved in proofreading and activity switching. | Nature Structural & Molecular Biology

Extended Data Fig. 4: Functional roles of Pol ε amino acid side chains involved in proofreading and activity switching.

From: Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol ε

Extended Data Fig. 4

Pol ε cat in complex with PCNA, substrate DNA and incoming nucleotide is shown as ribbons. The positions of selected amino acids are indicated by red spheres, numbered 1–10. The table lists the residues at the respective sites and their roles in the activity of Pol ε and/or other representative polymerases. References are: Kaushik 199661, Yang 200262, Parkash 202325, Bonnin 199926, Pursell 200763, Ganai 201531, Zakharova 200447, Ren 201664, Dahl 202248, Hogg 201417, Dua 200216, Aria 201952. Abbreviation: S. c., Saccharomyces cerevisiae.

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