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Membrane proteins

Insights into phosphate homeostasis regulation by XPR1

Nature Structural & Molecular Biology volume 32, pages 5–7 (2025)Cite this article

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XPR1 is the only annotated phosphate exporter protein in humans. Recent studies provide mechanistic clues to its cellular function; three posit non-export mechanisms to regulate phosphate homeostasis, while six present high-resolution cryo-EM data supporting a bona fide phosphate channel mechanism controlled by intracellular phosphate levels.

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Fig. 1: Putative non-export homeostatic mechanisms for XPR1.
Fig. 2: Structural basis for the regulated phosphate channel activity of XPR1.

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Acknowledgements

The author acknowledges C. Navarro for helpful guidance regarding the scope and text of this News & Views.

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  1. Department of Systems Biology, UMass Chan Medical School, Worcester, MA, USA

    Daniel P. Bondeson

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  1. Daniel P. Bondeson
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Correspondence to Daniel P. Bondeson.

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D.P.B. receives research support from Deerfield Management.

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Bondeson, D.P. Insights into phosphate homeostasis regulation by XPR1. Nat Struct Mol Biol 32, 5–7 (2025). https://doi.org/10.1038/s41594-024-01460-x

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