Aneuploidy is a major cause of embryonic failure and miscarriage. A new study identifies genetic variants of ELL3 associated with miscarriage and discovers a novel role for ELL3 in female meiosis.
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Acknowledgements
B.M. and T.C. are supported by the Swiss SNF grant 320030-228142 and by the University Research Priority Program ‘Human Reproduction Reloaded’ of the University of Zurich. The authors thank C. Thomas (IBDM, Marseille, France), S. Makieva (USZ-UZH, Zurich, Switzerland) and the members of the Cavazza lab for useful feedback and discussion.
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B.M. and T.C. wrote the manuscript and created the figure.
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Magerl, B., Cavazza, T. ELL3 regulates spindle assembly to prevent maternally inherited aneuploidy and infertility. Nat Struct Mol Biol 32, 217–219 (2025). https://doi.org/10.1038/s41594-024-01475-4
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DOI: https://doi.org/10.1038/s41594-024-01475-4
