Fig. 4: Atovaquone-bound structures of the T. gondii and mammalian CIII reveals the structural basis for species-specific Qo site binding.
From: Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex
a, View of the Qo site of T. gondii occupied by atovaquone, which prevents electron transfer to heme bL and Fe2S2 in the lumenal domain of the Rieske subunit, which occupies the b-state. Residues responsible for apicomplexan-specific atovaquone sensitivity are shown in red. b, A ligand diagram of atovaquone interactions in the T. gondii Qo site. c, View of the Qo site of C. sabaeus occupied with atovaquone. d, A schematic of atovaquone interactions in the C. sabaeus Qo site.
