Fig. 3: RMP24 is predicted to have structural homology with RPP21.
From: RNase MRP subunit composition and role in 40S ribosome biogenesis
a, Cartoon representation of the structure of RMP24, predicted by AlphaFold. b, A cartoon representation of the predicted structure of human RNase MRP, created using AlphaFold 3 (ref. 47). The magnified view to the right of the full structure highlights the predicted contacts between RMP24 and RPP29. c, A representative chromatogram from two biological replicates, resulting from passing the RMP24–RPP29 complex over a Superdex S200-increase column. A Coomassie-stained SDS–PAGE gel shows the peak fractions eluted from the Superdex S200-increase column. A table showing the peptide spectrum matches (PSMs) and coverage of RMP24 and RPP29 obtained from injecting the purified complex on the LC–MS. d, An illustration of the predicted structure of RMP24 (residues 1–127) and RPP21 (residues 4–124) from PDB ID 6AHR and an overlay of the two structures61.
