Extended Data Fig. 1: C18orf21 is associated with the shared subunits of the RNase P and RNase MRP complexes.
From: RNase MRP subunit composition and role in 40S ribosome biogenesis
(a) A waterfall plot showing the genes with the highest Pearson correlation of CRISPR-Cas9 based targeting effect scores to C18orf21 in the Depmap database (Depmap Public 23Q4). The shared RNase P and MRP components are shown in orange. Genes involved in rRNA processing are shown in purple and genes involved in tRNA processing are shown in green. (b) A waterfall plot showing the genes with the highest Pearson correlation of CRISPR-Cas9 based targeting effect scores to RPP21 in the Depmap database (Depmap Public 23Q4). The shared RNase P and MRP components are shown in orange. Genes involved in rRNA processing are shown in purple and genes involved in tRNA processing are shown in green. (c) A heat map showing the scaled relative precursor ion abundances of each RNase P/MRP component immunoprecipitated from cell lines ectopically expressing the indicated GFP tagged construct.
