Extended Data Fig. 7: The interactions between DNMT3 complexes and nucleosomes. | Nature Structural & Molecular Biology

Extended Data Fig. 7: The interactions between DNMT3 complexes and nucleosomes.

From: Mechanisms of DNMT3A–3L-mediated de novo DNA methylation on chromatin

Extended Data Fig. 7

a, AlphaScreen photo accounts for the interaction of His-tagged DNMT3A2, DNMT3A2-3B3, DNMT3A2-3L, DNMT3B3, and DNMT3L titrated against modified nucleosomes. Data were presented as mean ± s.e.m. of n = 4-13 biological repeats specified in each experiment. b, The full panel of DNMT3A2 nucleosomes binding strength (EC50) in AlphaScreen assay.

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