Extended Data Fig. 6: Structural comparison of the Ca2+/PtdIns(4,5)P2-bound open TRPM4 (this study) and Ca2+/DVT-bound open TRPM4 at 37oC (PDB: 9B8Y).
From: Structural landscape of activation, desensitization and inhibition in the human TRPM4 channel
a Superposition of the two open state structures with the front subunit highlighted in blue and orange for the Ca2+/PtdIns(4,5)P2-bound and Ca2+/DVTwarm-bound structures, respectively. The region encompassing the PtdIns(4,5)P2 and DVT binding sites is boxed. b Zoomed-in view of the PtdIns(4,5)P2 (top) and DVT (bottom) binding sites with ligand-interacting residues shown in stick representation.
