Fig. 4: Conformational changes at the cytosolic region of hTRPM4 upon channel activation.
From: Structural landscape of activation, desensitization and inhibition in the human TRPM4 channel
a, Structural comparison of TRPM4 between open and closed states. The front subunits are highlighted in blue (open) and wheat (closed) with TRP domain and MHR domains boxed in red. b, Zoomed-in view of the conformational changes at the interface between TRP helix 1 and the MHR4 domain. Red arrow marks the rotation movement of TRP helix 1. c, Conformational changes at the MHR domains. Red arrows mark the upward swing of MHRs domains and the rotation of MHR1 and MHR2. The conformational changes at the cytosolic region are visualized in Supplementary Video 3.
