Fig. 5: Putative desensitization of hTRPM4.
From: Structural landscape of activation, desensitization and inhibition in the human TRPM4 channel
a, Structure of Ca2+-bound putative desensitized TRPM4 with the F935–F910′ interface region boxed. The front subunit and its neighboring S1–S4 domain are highlighted in salmon and light salmon, respectively. b, Zoomed-in views of the F935–F910′ interface regions in the open (top), putative desensitized (middle) and closed (bottom) states. The F910′ and F935 side chains are shown in yellow. The EM density maps for F935, F910′ and their surrounding areas are shown in gray surface contoured at 0.2 in ChimeraX.
