Extended Data Fig. 8: Characterization of transcription recovery clusters after NELF-B degradation.
From: Evolution of promoter-proximal pausing enabled a new layer of transcription control
a) Bar plots depict the percentage of transcribed enhancers and gene promoters in each cluster defined in Fig. 5e (cluster 1: n = 8,030, cluster 2: n = 16,078, cluster 3: n = 3,792). b) Enrichment profiles of the pause motif published previously49 plotted in a 1 kb window centered on TSSs found in each of the clusters defined in Fig. 5e. c) Violin plots depict log10 transformed initiation (right) or pause release (left) rates in each cluster. A two-sided Mann-Whitney test was used to compute p-values, where n.s. defines non-significant p-values, and (***) p-values < 2.2e-16. d) Plots depict the enrichment of the TATA box, Initiator, MTE, and DPE sequence motifs in each cluster in Fig. 3e. e) Meta profiles depict the enrichment of TBP, TAF-12, TFIIA, TFIIB, H3K9ac, and Med1 per cluster. ChIP-seq data from ref.66.
