Extended Data Fig. 10: Correlations between heat shock PRO-seq data.
From: Evolution of promoter-proximal pausing enabled a new layer of transcription control
a) Principal component analysis (PCA) of non-heat shock (NHS), dTAG-13 treatment (dTAG), heat shock (HS), and a pre-treatment of dTAG-13 followed by heat shock (HS+dTAG). b) WashU browser shots at the heat-triggered genes (Hist1h3b, Hsp1h1, Hist1h3b) in the NELF-B (a) and NELF-E (b) edited cell lines. c) Heatmaps of log2 fold changes in PRO-seq signal in NELF-B (left) and NELF-E tagged (right) cell lines. The heatmap rows depict fold changes relative to NHS for the following treatments: dTAG-13 treatment alone, HS alone, and dual treatment of dTAG-13 and HS.
