Extended Data Fig. 5: STD NMR of PfHT1 constructs and sugar transporter structures determined in the presence of substrates or a substrate-like molecules. | Nature Structural & Molecular Biology

Extended Data Fig. 5: STD NMR of PfHT1 constructs and sugar transporter structures determined in the presence of substrates or a substrate-like molecules.

From: A two-step mechanism for sugar translocation

Extended Data Fig. 5: STD NMR of PfHT1 constructs and sugar transporter structures determined in the presence of substrates or a substrate-like molecules.

a. (left) STD (colored) and 1H spectra (black) of D-glucose in the presence of WT (red) or sugar-binding site mutants of PfHT1 (colored individually). (right) As in the left panel but for 2,5-AHM. b. Sugar transporters structures resolved in complex with a substrate or substrate-like molecule are presented, from the top left PfHT1 (PDB: 6RW3), XylE (PDB: 4GBY), XylE (PDB: 4GBZ), STP10 (PDB: 6H7D), STP10 (PDB: 7AAQ), from the bottom left PfHT1 (PDB: 6M20), GLUT3 (PDB: 7SPT), GLUT9 (PDB: 8Y65), STP6 (PDB: 9G11), STP10 (PDB: 7AAR), with protein shown as cartoons in gray, the ligand as sticks in teal and the lipids/detergents present to stabilize the structure as purple sticks.

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