Tandem duplications are frequent forms of genomic rearrangements with important implications in cancer biology and plant adaptation. Two new studies identify TONSL as a conserved suppressor of large tandem duplications by preventing the repair of broken replication forks through mutagenic mechanisms.
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Acknowledgements
This work was supported by grant PID2022-140393NB-I00 funded by MCIN/AEI/10.13039/501100011033 and European Regional Development Fund (ERDF) ‘A way of making Europe,’ by the European Union. E.L.-J. was supported by an Investigator grant from the Spanish Association Against Cancer (AECC) Scientific Foundation (INVS258462LOPE).
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E.L.-J. and C.G.-A. wrote the manuscript and created the figure.
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Lopez-Jimenez, E., González-Aguilera, C. TONSL emerges as a key barrier to prevent large tandem duplications. Nat Struct Mol Biol (2026). https://doi.org/10.1038/s41594-026-01793-9
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DOI: https://doi.org/10.1038/s41594-026-01793-9
