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RNA localization

Cracking the (zip)code of dynein-dependent RNA localization

Nature Structural & Molecular Biology (2026)Cite this article

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Subcellular mRNA localization relies on the recognition of cis-regulatory elements by trans-acting complexes, which mediate mRNA recruitment to the transport machineries. A study now defines the previously unclear rules that govern mRNA recognition by the Egalitarian–BicaudalD complex, a trigger for dynein-dependent transport.

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Fig. 1: Architecture of the Egl–BicD complex that mediates transport of target RNAs along microtubules.
The alternative text for this image may have been generated using AI.

References

  1. Medioni, C., Mowry, K. & Besse, F. Development 139, 3263–3276 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Chekulaeva, M. Nat. Cell Biol. 26, 1037–1046 (2024).

    Article  CAS  PubMed  Google Scholar 

  3. Dienstbier, M., Boehl, F., Li, X. & Bullock, S. L. Genes Dev. 23, 1546–1558 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Nicastro, G. et al. Cell Rep. 18, 1187–1199 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Patel, V. L. et al. Genes Dev. 26, 43–53 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Arora, A. et al. Nucleic Acids Res. 50, 10626–10642 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Mendonsa, S. et al. Nat. Neurosci. 26, 394–405 (2023).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Mikl, M. et al. Nucleic Acids Res. 50, 10643–10664 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Singh, K., Chilaeva, S., McClintock, M. A., Carter, A. P. & Bullock, S. L. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-026-01794-8 (2026).

    Article  Google Scholar 

  10. Bullock, S. L. & Ish-Horowicz, D. Nature 414, 611–616 (2001).

    Article  CAS  PubMed  Google Scholar 

  11. McClintock, M. A. et al. eLife 7, e36312 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Sladewski, T. E. et al. eLife 7, e36306 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Serano, T. L. & Cohen, R. S. Development 121, 3809–3818 (1995).

    Article  CAS  PubMed  Google Scholar 

  14. Spitale, R. C. & Incarnato, D. Nat. Rev. Genet. 24, 178–196 (2023).

    Article  CAS  PubMed  Google Scholar 

  15. Arora, A. et al. Front. Genet. 12, 818668 (2021).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

F.B. is supported by the CNRS and by ANR grants (ANR-22-CE12-0024; ANR-25-CE13-7457).

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Authors and Affiliations

  1. Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose, Nice, France

    Florence Besse

  2. Research Department of Structural and Molecular Biology, University College London, London, UK

    Andres Ramos

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  1. Florence Besse
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  2. Andres Ramos
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Correspondence to Florence Besse or Andres Ramos.

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Besse, F., Ramos, A. Cracking the (zip)code of dynein-dependent RNA localization. Nat Struct Mol Biol (2026). https://doi.org/10.1038/s41594-026-01808-5

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