Table 1 Statistics related to the performance evaluation of three SDAs for DDIs using FAERS data.

From: A reference set of clinically relevant adverse drug-drug interactions

Citation

SDA

Performance analysis in the original source

AUC (95% CI)

Medians

Score+

Score−

Noren et al., 20088

Omega

a. 5 positive examples (case studies);

b. World Health Organization (WHO) database-wide screen

0.5670

(0.5534, 0.5806)

−1.6173

−2.3151

Thakrar et al., 20079

delta_add

4 positive and 4 negative controls tested on FAERS

0.4211

(0.4110, 0.4312)

0.00078

0.00417

Almenoff et al., 200310

IntSS

Beta blockers + Verapamil (as positive controls) and

Angiotensin-converting enzyme (ACE) inhibitors/Angiotensin-2 receptor blockers + Verapamil (as negative controls) tested on FAERS for impaired myocardial conduction

0.5041

(0.4921, 0.5162)

0.3669

0.3453

  1. AUC, area under the receiver operating characteristic curve; Score+, median signal score for the set of positive controls; Score−, median signal score for the set of negative controls.
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