Fig. 6

Reliability of miRNA-mRNA integration (a) Principal variance component analysis (PVCA) shows the relative contribution of main effects (organ, age, sex, and replicate) and interactions (:) to total model variance in miRNA (blue) and gene (red) expression. Effects in the Y-axis are ordered by proportion of overall variations explained in the miRNA dataset. (b) Pairwise correlations between all 10,418,396 miRNA-gene pairs (604 miRNAs versus 17,249 genes), 20 intragenic miRNAs on opposite strand of host genes, 147 intragenic miRNAs on the same strand of host genes.