Fig. 6
Expression of virulence factors sodA and sodM in S. aureus tends to diverge under different experimental conditions. Volcano plots of all genes are shown to demonstrate the expression values of sodA and sodM relative to other genes detected. (a,b) In co-culture with P. aeruginosa, both sodA and SodM expression are upregulated, sodA to a much greater extent. (c,d). In ‘persister cells’, the expression pattern was quite different: sodM expression was more markedly upregulated while sodA expression was downregulated (e,f). Finally, exposure to apicidin was found to induce downregulation of sodA, but no significant change in sodM. In all cases, aside from sodM expression in (f) sodA and sodM were differentially expressed to a statistically significant degree (p < 0.05).
