Fig. 1
From: Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways
Quantitation of core TLR4 pathway proteins within mouse BMDMs. LC-PRM assays were performed to quantitate proteins of the core TLR4 pathway. Some proteins were targeted but were not detected (white nodes), possibly because their abundance was below the limit of detection of the LC-MS. Selected clusters of nodes are indicated by encircled numbers: 1. TLR4 receptors, 2. myddosome signaling complex, 3. triffosome signaling complex, 4. programmed cell death, 5. K63 and M1 polyubiquitination, 6. negative regulators, 7. NFÎşB pathway, 8. MAP kinase signaling, 9. transcription factors. This signaling network is described in detail in our earlier article1. n.d., not detected. n.t., not targeted.
