Fig. 6
A relatively large number of DEGs in males responding to sciatic nerve injury and identification of four male-specific markers expressed in DRG. (a) Schema of compared groups. (b) Manhattan plots showed DEGs in four compared groups. Orange points indicated significantly up-regulated genes while green indicated significantly down-regulated genes. Gene ranking was ordered based on π-value. Top 15 up-regulated and top 5 down-regulated genes were labeled. Four male-specific markers were shaded. (c) Expression of four male-specific markers in four datasets. (d) Upset plots of the relationship of DEGs identified from four compared groups in each dataset. (e) Venndiagram of common injury genes in rats and mice. (f,g) Scatter plots of male- or female-preference DEGs in rat and mice upon ScNI. Eight clusters with distinct colors were divided based on the cutoff of fold-change (1.5, red dotted lines). Number shaded with colorful boxes indicated DEG numbers in each cluster. Importantly enriched GO terms in a cluster were shown.
