Fig. 3
From: Three-dimensional chromatin architecture datasets for aging and Alzheimer’s disease
Hi-C interaction sites overlap with promoters and enhancers. (a) Graph illustrating that 82.7% of loops were overlapped with active chromatin regions, which were defined by H3K27ac marks and ATAC-seq peaks.(b) Compartment analysis indicated that the transcription start sites were more associated with active looped interactions. (c) Chromatin-looped interactions were correlated with the gene expression changes. Boxplot analysis showed the fold changes of long-distance interactions and gene expression, indicating that the dynamic of 3D-chromatin architecture contributed to gene expression changes.
