Fig. 3

Examples supporting the technical validation of the QTAB non-imaging phenotypes. Within the 5-year funding period, the accelerated longitudinal design maximised the benefits of cross-sectional and longitudinal data collection (a), and developmental changes in pubertal status (b) and processing speed (c) occurred between sessions 1 and 2. The QTAB cohort was highly representative of community norms in cognitive ability (d), with the expected genetic relationship, i.e., identical twins were more alike than non-identical twins (e). In addition, the tools chosen to measure depression (f) and anxiety (g) were sensitive enough to capture individual differences and identify at-risk individuals. Variability in a depression risk factor, i.e., daytime sleepiness (h), was consistent with other community samples.