Fig. 6 | Scientific Data

Fig. 6

From: Quantitative Mass Spectrometry Analysis of Cerebrospinal Fluid Protein Biomarkers in Alzheimer’s Disease

Fig. 6The alternative text for this image may have been generated using AI.

Differential expression analysis across stages of AD. ANOVA analysis with Tukey post hoc FDR was performed for pairwise comparison of mean log2(ratio) differences between the 3 stages of AD (i.e., Control, AsymAD and AD) of N = 390 total case samples and plotted as a volcano. Significance threshold for counting of peptides was p < 0.05 (dashed horizontal line). Differentially expressed peptides for (a) AsymAD (N = 127) versus control (N = 133), (b) AD (N = 130) versus control, and (c) AD versus AsymAD are labeled by their gene symbols. (d) Counts of peptides with significant difference in any of the 3 dichotomous comparisons are presented as a Venn diagram. Full statistics from the ANOVA and Tukey post-hoc analysis is presented in the ANOVA table in the Data folder deposited on Synapse25.

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