Table 4 List of broad cell type marker genes used to allocate cell types to clusters.

From: Meta-analysis of single-cell and single-nucleus transcriptomics reveals kidney cell type consensus signatures

A. scRNA-seq markers

Cell type

Markers

Immune

Macro.

Macrophage

CD6837,45,46

S100A846

S100A946

FCN152

LILRA546

 

DC

Dendritic cells

CD6846

FCER1A45

CLEC10A46

   

B.cells

B cells

CD79A37,45,46

MS4A145,46

    

CD4.T.cells

CD4 T cells

CD3D45,46

IL7R45,46

    

CD8.T.cells

CD8 T cells

CD3D45,46

NKG746

GZMA37,47

GNLY48

  

NK.cells

Natural killer cells

NKG746

GZMA47

GNLY48

   

Vascular

EC.vei

Endothelial cells, veinous

EMCN9,22,37

ENG22,37,38

PLAT22

PLVAP22,37

  

EC.glom

Endothelial cells, glomerular

EMCN9,22,37

ENG22,37,38

PLAT22

EHD338

  

EC.art

Endothelial cells, arterial

EMCN9,22,37

ENG22,37

CAV138

   

vSMC

Vascular smooth muscle cells

ACTA29,41

TAGLN37

CAV142

PDGFRB39

  

Fibro.

Fibroblasts

PLK250

PLK351

    

Nephron epithelail cells

Podo.

Podocytes

NPHS26,9,22,37

PODXL6,22,37

CTGF22

CTGF22

  

PEC

Parietal epithelial cells

CRYAB22

CFH22

CTGF22

VCAM122

  

PTC

Proximal tubule cells

CRYAB22

MIOX22

ALDOB22

APOE22

  

LoH.DTL

Descending thin limb of the loop of Henle cells

CRYAB6,9

VCAM19

CLDN449

   

LoH.ATL

Ascending thin limb of the loop of Henle cells

CLDN109,49

SLC12A122

CLDN449

   

LoH.TAL

Thick ascending limb of the loop of Henle cells

SLC12A16,9,22,37

UMOD6,9,22,37

KNG16,9,22

CLDN1054

  

DCT

Distal contourned tubule cells

SLC12A36,9,37

CALB19,22

KNG122

   

CNT

Connecting tubule cells

CALB16,9,22,37

SLC8A16,9,22

KNG122

   

PC.CNT

Principal cells, connecting tubule

CALB16,22

AQP26,22

AQP36,22

FXYD46

  

PC.CD

Principal cells, collecting duct

AQP26,9,22,37

AQP36,9,22,37

FXYD46,9,22,37

   

IC.A

Intercalated cells, A-type

SLC4A16,9,22,37

FOXI16,9,22

DMRT29,22

ATP6V1G322

APOE53

 

IC.B

Intercalated cells, B-type

SLC26A49,22,37

INSRR22,37

ATP6V1G322

FOXI122

  

B. snRNA-seq markers

Vascular

EC.vei

Endothelial cells, veinous

EMCN9,22,37

ENG22,37,38

PLVAP22,37

   

EC.glom

Endothelial cells, glomerular

EMCN9,22,37

ENG22,37,38

KDR22,37,38

EHD338

CD3437

ITGA822

EC.art

Endothelial cells, arterial

EMCN9,22,37

ENG22,37,38

CD3422,38

VEGFC44

  

vSMC

Vascular smooth muscle cells

ACTA29,41

PDGFRB39

ITGA843

   

Mes.

Mesangial cells

PDGFRB9,39

ITGA89,22,40

EMCN22

ENG22

COL12A122

 

Fibro.

Fibroblasts

COL12A122

COL6A222

    

Nephron epithelail cells

Podo.

Podocytes

NPHS26,9,22,37

WT16,22,37

    

PEC

Parietal epithelial cells

CTGF22

CFH22

WT122

CRYAB22

  

PTC

Proximal tubule cells

MIOX6,22,99

GPX36,9

CUBN6,9

ALDOB22

  

LoH.DTL

Descending thin limb of the loop of Henle cells

CRYAB6,9

VCAM19

CLDN449

CUBN54

  

LoH.ATL

Ascending thin limb of the loop of Henle cells

SLC12A122

CLDN449

UMOD54

   

LoH.TAL

Thick ascending limb of the loop of Henle cells

SLC12A16,9,22,37

UMOD6,9,22,37

KNG16,9,22

   

DCT

Distal contourned tubule cells

SLC12A36,9,37

KNG122

    

CNT

Connecting tubule cells

CALB16,9,22,37

SLC8A16,9,22

KNG1

   

PC.CNT

Principal cells, connecting tubule

AQP222

SLC8A122

CALB122

   

PC.CD

Principal cells, collecting duct

AQP26,9,22,37

AQP36,9,22,37

FXYD46,9,22,37

   

IC.A

Intercalated cells, A-type

SLC4A16,9,22,37

FOXI16,9,22

DMRT29,22

ATP6V1G322

  

IC.B

Intercalated cells, B-type

SLC26A49,22,37

INSRR22,37

FOXI122

ATP6V1G322