Fig. 1
From: A harmonized resource of integrated prostate cancer clinical, -omic, and signature features
Gene expression patterns across datasets. (a) Pearson correlation between datasets comparing differential expression of Gleason grade ≥8 vs. Gleason grade ≤6 samples for genes common between the datasets. (b) Volcano plots for differential gene expression comparing Gleason grade ≥8 vs. Gleason grade ≤6 samples. The highlighted genes are the top five up- and down-regulated genes identified across the four datasets using Fisher’s method to combine p-values. (c) Spearman’s rank correlations for all genes within the dataset were calculated compared to AR and the ETS transcription factor, ERG. The Spearman correlation was calculated for the correlation patterns between datasets and displayed for AR (left side) and ERG (right side) in both primary and metastatic tumors.
