Fig. 1

Some ICPs and lncRNAs are highly expressed in multiple immune cell types. (a) The heatmap shows numbers of samples for different immune cell types after removing batch effect in diverse datasets. (b) The point plots show two datasets (pink and blue-green) before and after removing batch effect in B cell. (c) Top bar chart shows up- (red) and down-regulated (blue) highly expressed ICPs between cancer and normal tissues in TCGA. The bubble plot shows fold change and P values of differential expressed ICPs across cancer types. (d) The heatmap shows dysregulation of highly expressed lncRNAs across cancer types. Right bar chart shows up- (yellow), down- (blue) regulation and non-significance (Grey).